Do multivitamin supplements modify the relationship between prenatal alcohol intake and miscarriage?

Do multivitamin supplements modify the relationship between prenatal alcohol intake and miscarriage?

OBJECTIVE: To determine whether multivitamin supplements modify
the relationship between alcohol consumption during pregnancy and
the risk of miscarriage.
STUDY DESIGN: We used data from a population-based cohort study of
pregnant women (n �� 1061; response rate �� 39%). Participants were
asked about their alcohol consumption and vitamin intake during
pregnancy.
RESULTS: Among multivitamin nonusers, women who drank alcohol
during their pregnancy were more likely to have a miscarriage com-
pared with women who abstained (adjusted hazard ratio, 1.67; 95%
confidence interval, 1.04 –2.69). However, among multivitamin users,
there was no difference in the risk of miscarriage between alcohol con-
sumers and abstainers. Results suggest the volume of alcohol as well
as the timing of multivitamin supplementation may also be important.
CONCLUSION: Our findings suggest that a woman of childbearing years
might decrease her risk of miscarriage associated with alcohol intake by
taking multivitamin supplements. However, our findings should be in-
terpreted with caution and future research replicating these findings is
necessary.
Key words: alcohol consumption during pregnancy, miscarriage,
multivitamin supplementation, reproductive outcomes

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Lyndsay Ammon Avalos, PhD, MPH; Lee Ann Kaskutas, DrPH; Gladys Block, PhD; De-Kun Li, MD, PhD

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